The Trailing End Point Phenotype in Antifungal Susceptibility Testing Is pH Dependent
نویسندگان
چکیده
منابع مشابه
Antifungal susceptibility testing.
Antifungal susceptibility testing has been in routine use now for more than 15 years and has become a useful tool for clinicians who are faced with difficult treatment decision. Although most clinicians order susceptibility testing, much confusion still exists regarding the use of the results. Sufficient data have been generated to determine susceptibility trends for specific fungi against spec...
متن کاملPersonalized antifungal susceptibility testing.
Introduction In recent years, the remarkable increase in the number of infections caused by fungal pathogens, especially in immunocompromised people, has stimulated interest in medical mycology in general and in antifungal susceptibility testing in particular. 1,2 In-vitro procedures for determining the activity of drugs against mould and yeast isolates involve clinicians in the choice and moni...
متن کاملIssues in antifungal susceptibility testing.
In line with the availability of an increasing array of systemic antifungal agents, there is a need for accurate, reproducible and predictive susceptibility testing of fungal isolates in order to help inform clinical choice. Much early attention on antifungal susceptibility testing focused on defining test parameters that produced reproducible and reliable intra- and inter-laboratory results an...
متن کاملTrailing end-point phenotype antibiotic-sensitive strains of Candida albicans produce different amounts of aspartyl peptidases.
Candida albicans is an opportunistic fungal pathogen that causes severe systemic infections in immunosuppressed individuals. C. albicans resistance to antifungal drugs is a severe problem in patients receiving prolonged therapy. Moreover, trailing yeast growth, which is defined as a resistant MIC after 48 h of incubation with triazole antifungal agents but a susceptible MIC after 24 h, has been...
متن کاملThe evolving role of antifungal susceptibility testing.
Although increasing numbers of hospital microbiology laboratories are performing antifungal susceptibility testing (AST), its routine use is uncommon. The utility of AST is founded on the belief that susceptibility (or resistance) of an agent allows some prediction of clinical outcome. This review provides an overview of the development of antifungal susceptibility testing methodology, includin...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1999
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.43.6.1383